Pseudokinase drug intervention: a potentially poisoned chalice.

The White Paper: opportunity or poisoned chalice?

The dark side of trust: When trust becomes a ‘poisoned chalice’

Trust is typically portrayed as beneficial to all concerned; something which is inherently good. In this article we focus on interpersonal trust and argue that, while there are undoubted benefits, trust can also be problematic; there are circumstances in which it can become a ‘poisoned chalice’ for one or other of the parties involved. We question whether the potential for negative experiences ...

Application of the CHALICE clinical prediction rule for intracranial injury in children outside the UK: impact on head CT rate.

OBJECTIVE The children's head injury algorithm for the prediction of important clinical events (CHALICE) is one of the strongest clinical prediction rules for the management of children with head injuries. The authors set out to determine the impact of this rule on the proportion of head injured patients receiving a CT scan in a major Australian paediatric emergency department. DESIGN Retrosp...

The Rudd reforms: a poisoned chalice in the long run.

The Medical Journal of Australia ISSN: 0025729X 3 May 2010 192 9 1-2 ©The Medical Journal of Australia 2010 www.mja.com.au Viewpoint power are, at best, overstated. Although the Comm greater fiscal power and can ensure stable, long-ter would be better to reform the tax system to meet th health system than compromise health care delivery antiquated tax system. As noted in two articles i (recentl...

Mechanistic Insights into Regulation of JAK2 Tyrosine Kinase

JAK2 is a member of the Janus kinase (JAKs) family of non-receptor protein tyrosine kinases, which includes JAK1-3 and TYK2. JAKs serve as the cytoplasmic signaling components of cytokine receptors and are activated through cytokine-mediated trans-phosphorylation, which leads to receptor phosphorylation and recruitment and phosphorylation of signal transducer and activator of transcription (STA...